Trephenol™−A Patented and Clinically Evaluated Blend of Key Olive Polyphenolsa


The Mediterranean Diet–A Lifestyle for Today

The Mediterranean diet, which is rich in plant foods, olive oil, and fish and seafood, refers to the diet practices and foods commonly eaten in the Mediterranean region (for example, in Greece and Italy).1,2 The Mediterranean diet has evolved to fit today’s lifestyle based on expert scientific consensus, research in the field of nutrition and health, and scientific evidence with regard to the health benefits observed in large group studies published in peer-reviewed scientific journals.1 The diet is associated with various health benefits.

Trephenol™, OliVentures’ foundational ingredient, is a patented blend of key olive polyphenols that includes hydroxytyrosol and tyrosol—2 extensively studied polyphenols in olive oil. Olives and olive oil are essential components of the Mediterranean diet.1-10

Hydroxytyrosol and tyrosol are 2 extensively studied polyphenols in olive oil.11 Scientific research into olive nutrition is an exciting area that is constantly revealing new insights into the specific health benefits of consuming olives, olive oils, and the polyphenols and other phytochemicals they contain. Importantly, this research has shown these substances to have antioxidant, antimicrobial, and anti-inflammatory properties.12,13

That’s why we include Trephenol™, our patented combination of the olive fruit polyphenols, hydroxytyrosol and tyrosol, in our products. Taking 2 softgels of PureVida™ containing Trephenol™  each day for a week delivers the equivalent amount of olive polyphenols (hydroxytyrosol and tyrosol) as 2.5 liters of olive oil without the added calories and unwanted fats, plus marine-based omega-3s (the equivalent EPA and DHA in over 3 fish meals per week).

Preclinical in vitro testing of Trephenol™ conducted by OliVentures in the U.S. has successfully validated some of the reported antioxidant and anti-inflammatory properties of hydroxytyrosol and tyrosol in the areas of cardiovascular and breast health. An initial clinical trial of PureVida™ in Spain (with 45 patients) has suggested health benefits for women taking aromatase inhibitors.a,*,14

Because only one trial, with 45 participants, has been performed (and the results of the trial have not yet been peer reviewed), more research is needed to confirm that the results of that trial are valid.a

At OliVentures, we will continue to monitor olive nutrition research in order to use the new discoveries to help develop formulations that can tap into the potential health benefits that are constantly being revealed.

Feel the Benefits of the PureVida Power of 3™

  • Supports Heart, Breast, and Joint Health*
  • Clinically evaluateda
  • Formulation patent-pending

aIn a prospective, multicenter, pilot study of 45 postmenopausal women (mean age 59 years) with Stage 0-IIIA hormone receptor−positive breast cancer receiving stable doses of adjuvant aromatase inhibitor therapy for 2 to 5 years from their diagnosis, PureVida™ significantly reduced C-reactive protein (CRP) levels (p<0.05). In 45 patients examined for safety, reported adverse events (AEs) included abdominal pain in 1 patient (2.2%), constipation in 5 patients (11.1%), headache in 3 patients (6.7%), and abnormal product taste (fish taste) in 14 patients (31.1%). No patients had to discontinue therapy due to AEs. This study was conducted by OliVentures. There has been substantial separate research into the potential benefits of each of the ingredients in PureVida™. The PureVida™ trial has not been peer reviewed and more research is needed before drawing any final conclusions.

*This product is not intended to diagnose, treat, cure, or prevent any disease. Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. Limited clinical evidence indicates that PureVida™ may lower elevated CRP levels. CRP is one of several markers of inflammation in the body. Limited clinical evidence indicates that PureVida™ may reduce joint pain in women taking aromatase inhibitors. These statements have not been evaluated by the U.S. Food and Drug Administration (FDA).

  1. Bach-Faig A, Berry EM, Lairon D, et al. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr. 2011;14(12A):2274-2284.
  2. Mediterranean diet. Mayo Clinic website. Updated March 30, 2017. Accessed April 10, 2017.
  3. Munoz MA, Fito M, Marrugat J, et al. Adherence to the Mediterranean diet is associated with better mental and physical health. Br J Nutr. 2009;101(12):1821-1827.
  4. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348(26):2599-2608.
  5. Tong TY, Wareham NJ, Khaw KT, Imamura F, Forouhi NG. Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study. BMC Med. 2016;14(1):135.
  6. Perk J, De Backer G, Gohlke H, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur J Prev Cardiol. 2012;19(4):585-667.
  7. Toledo E, Salas-Salvado J, Donat-Vargas C, et al. Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED trial: a randomized clinical trial. JAMA Intern Med. 2015;175(11):1752-1760.
  8. Bonaccio M, Di Castelnuovo A, Bonanni A, et al. Adherence to a Mediterranean diet is associated with a better health-related quality of life: a possible role of high dietary antioxidant content. BMJ Open. 2013;3(8).
  9. Oil, olive, salad, or cooking. Self Nutrition Data website. Accessed April 3, 2017.
  10. Ortega R. Importance of functional foods in the Mediterranean diet. Public Health Nutr. 2006;9(8A):1136-1140.
  11. Peyrol J, Riva C, Amiot MJ. Hydroxytyrosol in the prevention of the metabolic syndrome and related disorders. Nutrients. 2017;9(3).
  12. Cicerale S, Lucas LJ, Keast RS. Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr Opin Biotechnol. 2012;23(2):129-135.
  13. Cicerale S, Conlan XA, Sinclair AJ, Keast RS. Chemistry and health of olive oil phenolics. Crit Rev Food Sci Nutr. 2009;49(3):218-236.
  14. Data on file. OliVentures, Inc. Raleigh, NC.